|
KMID : 0366919990110000389
|
|
Sungkyun Pharmceutical Journal
1999 Volume.11 No. 0 p.389 ~ p.392
|
|
|
Inducible Nitric Oxide Synthase Inhibitors from Melia azedarach var.Japonica
|
|
Kwon, Hak Cheol
Lee, Byeong Gon/Kim, Seung Hee/Jung, Chil Mann/Hong, Sung Youl/Han, Jeung Whan/Lee, Hyang Woo
|
|
|
Abstract
|
|
|
|
In bioassay-guided search for inducible nitric oxide synthase (iNOS) inhibitory compounds from higher plants of South Korea, two β-carboline alkaloids, 4-methoxy-1-vinyl-β-carboline (1) and 4,8-dimethoxy-1-vinyl-β-carboline (2) have been isolated from the cortex of Melia azedarach var. japonica. The structures of these compounds were elucidated on the basis of spectroscopic data. Compounds 1 and 2 showed marked inhibitory activity of iNOS on LPS- and interferon-γ-stimulated RAW 264.7 cells.
|
|
|
KEYWORD
|
|
|
|
|
|
FullTexts / Linksout information
|
|
|
|
|
|
Listed journal information
|
|
|
|